
Mbeumo put the hosts in front just before halftime with a simple low finish, following up on Kevin Schade’s strike which bounced off the post.
He doubled the advantage in the 65th minute with a first-time shot into the bottom corner of the net and Wissa bundled the ball in four minutes later before Southampton pulled a goal back in stoppage time through Yukinari Sugawara.
Brentford moved up to fifth on six points while Southampton prop up the standings without a points.
Stay current - Follow FMT on WhatsApp, Google news and Telegram