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The bus with more than 40 occupants was headed for the Andean region of Ayacucho from Lima when it veered off a cliff about 200m high in the early morning hours, highway safety division director Jhonny Valderrama said on RPP radio.
Twenty people were taken with injuries to hospitals nearest the accident scene as rescue teams worked to recover bodies from the wreck.
Accidents are frequent on Peru’s often winding, mountainous roads due to speeding, poor road upkeep, a lack of traffic signs and lax enforcement of driving rules.
Last year, the country registered more than 3,130 deaths from traffic accidents.
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